Prometrium Progesterone Capsules

BUY PROMETRIUM PROGESTERONE CAPSULES FOR USE WITH ESTROGEL (ESTRADIOL GEL).

WHAT IS PROMETRIUM AND WHAT IS IT USED FOR?

Prometrium belongs to the pharmaceutical category of sex hormones. It is indicated for oral or vaginal use.

Oral use of Prometrium

Prometrium is used for disorders due to insufficient production of the hormone progesterone (progestogen insufficiency), in particular in case of:

- symptoms that precede menstruation (PMS);

- alterations of the cycle;

- breast lumps (benign mastopathies);

- menstrual irregularities in the period preceding the definitive cessation of the menstrual cycle (premenopause);

- menopausal hormone replacement therapy (in association with hormone therapy estrogen).

Vaginal use of Prometrium

Progesterone capsules Prometrium are used as:

- progestogen hormone supplement in the last phase of the menstrual cycle, after ovulation (luteal phase) during spontaneous or induced cycles, in case of reproductive capacity lower than

normal (hypofertility) or insufficient response of the ovaries to normal stimulation (primary or secondary ovarian failure);

- in the event of a threat of abortion or in the prevention of repeated abortions due to ascertained insufficient production of progesterone by the ovary in the last phase of the cycle menstrual (luteal insufficiency), up to the 12th week of absence of menstruation (amenorrhea).

WHAT YOU NEED TO KNOW BEFORE YOU TAKE PROMETRIUM PROGESTERONE CAPSULES

Do not take Prometrium progesterone capsules

- if you are allergic to progesterone, or to closely related substances from a chemical point of view or any of the other ingredients of this medicine;

- if you suffer from severe impairment of liver function (severe liver failure);

- if you have vaginal bleeding of an unknown nature;

- in case of internal or incomplete abortion;

- if you have or have suffered in the past from blockage of blood vessels caused by blood clots

(thromboembolism);

- if you have or suspect that you have cancer of the breast (breast cancer) or of the genital system;

- if you suffer from inflammation of the superficial veins associated with the formation of blood clots

(thrombophlebitis);

- if you have suffered a rupture of a blood vessel in the area of ​​the brain (cerebral haemorrhage).

WARNINGS AND PRECAUTIONS

Talk to your doctor or pharmacist before taking this medicine.

ADMINISTRATION OF PROMETRIUM PROGESTERONE CAPSULES

Always take progesterone capsules exactly as your doctor has told you. If in doubt, consult a medical professional.

The recommended doses must be absolutely respected.

The dose should not exceed 200 mg for each administration, independently of the indication and route of administration (oral or vaginal).

Oral use

On average, due to insufficient production of the hormone progesterone, the daily dose is 200-300 mg of progesterone.

It is recommended to take progesterone capsules between meals.

In case of insufficient production of progesterone by the ovary in the last phase of the cycle menstrual (luteal insufficiency), especially in premenstrual syndrome, diffuse nodularity

of the breasts (benign mastopathies), cycle alterations, premenopause, the daily dose is of 200-300 mg of progesterone, for a therapeutic cycle of 10 days, usually from the 17th to the 26th

including day of the cycle.

In postmenopausal hormone replacement therapy (HRT), estrogen monotherapy is not recommended due to the risk of thickening of the uterine lining (endometrial hyperplasia). The

progesterone should be administered at a dose of 200 mg per day for 12-14 days at month, or during the last two weeks of each therapeutic cycle.

HRT should be discontinued for about a week during which a vaginal bleeding may occur.

For these indications, in the case of liver disease and side effects due to progesterone (sleepiness after oral administration), vaginal use should be used as an alternative to oral use with the same doses.

Vaginal use

Insert each progesterone capsule deeply into the vagina.

As a supplement in the last phase of the menstrual cycle, post-ovulatory (luteal phase) during spontaneous or induced cycles, in case of reduced reproductive capacity or primary sterility or secondary, particularly in case of ovulation alteration, the daily dose recommended is 200-300 mg per day, starting on the 17th day of the cycle for 10 days, 4 of 6 consecutive. The treatment must be repeated, as soon as possible, in the absence of menstruation (amenorrhea) and confirmed pregnancy.

In case of miscarriage treatment or prevention of repeated miscarriages due to insufficient production of progesterone in the luteal phase, the recommended daily dose is 200-400 mg per day.

If you take more Prometrium than you should, notify your doctor immediately.

If you forget to take progesterone capsules Prometrium, do not take a double dose to make up for a forgotten previous dose.

POSSIBLE SIDE EFFECTS

Like all meds, progesterone capsules Prometrium can cause side effects, although not all people manifest them. Occasionally, there may be sleepiness and dizziness for up to three hours after oral administration of Prometrium. In this case the dose should be reduced or readjusted (for example: 1 capsule of 200 mg or 2 capsules of 100 mg at bedtime, for 12-14 days each cycle).

During the vaginal administration, the following effects have also been reported:

- shortening of the menstrual cycle or loss of blood from the uterus outside the menstrual periods (metrorrhagia). In these cases it is advisable to postpone the treatment for a few days (for

for example, start treatment on day 19 of the cycle instead of day 17).

The following undesirable effects have been reported following administration of progestogens in general: intermenstrual bleeding, changes in menstrual flow, absence of menstruation (amenorrhea), alteration of the cervical mucus, breast pain (mastodynia), change in body weight (increase or decrease), skin reactions (skin rash with or without itching), yellow-brown spots on the face during pregnancy (chloasma), fever, insomnia, nervousness, depression, headache.

ADDITIONAL INFORMATION ABOUT PROMETRIUM PROGESTERONE CAPSULES

Active Component: Micronized progesterone. Each capsule contains 100 mg of progesterone micronized or 200 mg of progesterone micronized. Excipients: sunflower oil, soy lecithin. The components of the capsule are gelatin, glycerol, titanium dioxide.

Volume & Packaging: a pack of Prometrium 100 mg contains 30 capsules; a pack of Prometrium 200 mg contains 15 capsules.

Storage Conditions: Store at 2℃ up to 25℃ in a cool, dry place. Keep out of the sight and reach of children. Do not use progesterone capsules after the expiry date which is stated on the package after “Expires on”. The expiry date refers to the last day of that month. The expiry date refers to product in intact packaging, properly stored. Do not throw any medicine via wastewater or household waste.

Prometrium progesterone capsules are manufactured in Italy.