Plinest and Newest by Mastelli: The Range and Its Indications

Mastelli, an Italian laboratory, is one of the names most associated with the polynucleotide category, and its Plinest and Newest lines are a common starting point for clinics building a regenerative menu. The range has grown to cover different areas and priorities, so a short map of the variants is useful.

Plinest — The Base of the Range

Plinest is the core facial polynucleotide: a purified polynucleotide gel intended to improve overall skin quality — elasticity, texture and hydration — across the face. For many clinics it is the default entry point into the category and the reference against which the other variants are positioned.

Plinest Fast

Plinest Fast is formulated for a more fluid delivery, which some practitioners prefer for broad, superficial distribution across an area. The regenerative intent is the same; the handling characteristics differ.

Plinest Eye

Plinest Eye is presented specifically for the delicate periorbital skin. The under-eye is thin, mobile and unforgiving, and a formulation positioned for this region is a natural fit for concerns such as crepiness and fatigue there — distinct from tear-trough volume loss, which is a filler question.

Plinest Hair

Plinest Hair extends the polynucleotide approach to the scalp, where the aim is to support the follicular environment. It is typically used within a wider hair-quality protocol rather than as a stand-alone answer to hair loss.

Plinest One

Plinest One is a single-session-oriented presentation within the family, offering a convenient option where a streamlined course suits the patient and the plan.

Newest and Newest One — Polynucleotides with Hyaluronic Acid

The Newest line combines polynucleotides with hyaluronic acid, pairing the regenerative signal of PN with the immediate hydrating, water-binding properties of HA. This makes it a useful choice where a practitioner wants both effects in one product — skin-quality support plus a more noticeable hydration boost. Newest One offers the same philosophy in a single-session-oriented format.

Choosing Between Them

In broad terms:

• Overall facial skin quality → Plinest (or Newest, if added hydration is wanted)
• Fluid, superficial distribution → Plinest Fast
• Under-eye skin quality → Plinest Eye
• Scalp / hair support → Plinest Hair
• Streamlined single-session course → Plinest One or Newest One

Treatment Course

Mastelli polynucleotides are generally used as a short course — commonly two to three sessions spaced a few weeks apart — with results building gradually and a maintenance session later in the year. As with any regenerative injectable, outcome depends heavily on baseline skin condition and patient selection.

Contraindications

Standard exclusions apply: hypersensitivity to any component, pregnancy and lactation, active infection or inflammation at the site, and bleeding disorders. As the polynucleotides are fish-derived, a fish-allergy history is a relevant screening question.

The Takeaway

The Mastelli range covers the main polynucleotide use-cases through clearly positioned variants — face, eye, scalp, single-session, and PN-plus-HA. Matching the variant to the concern is the main decision. Browse the full polynucleotide range or start with the 2026 polynucleotide guide.