Rejuran: Polynucleotides for Skin, Under-Eyes and Scalp

Rejuran is the Korean polynucleotide range that has done much to popularise the category worldwide. Built on purified polynucleotide technology, it is presented in a small family of formulations aimed at different areas and depths. Here is how they are usually distinguished.

Rejuran Healer

Rejuran Healer is the flagship skin-quality presentation. It is used to support overall skin condition — texture, elasticity, fine lines and resilience — through a course of micro-injections across the face. As with all polynucleotides, the effect is regenerative and builds over the weeks after treatment, rather than delivering an immediate change.

Rejuran i

Rejuran i is formulated for the under-eye area, where skin is especially thin and delicate. It is positioned for periorbital skin quality — crepiness, fine lines and a fatigued appearance — and is a different proposition from tear-trough filler, which addresses hollowing and volume rather than skin condition. Where both a skin-quality and a volume concern coexist, the two approaches can be sequenced rather than substituted.

Rejuran S

Rejuran S is a more targeted presentation, often reached for where a firmer, more localised placement suits the concern. It broadens the range beyond generalised skin quality toward specific, focal work.

Indications

Across the range, Rejuran is positioned for:

• Overall skin texture, elasticity and fine lines
• Dull, fatigued or dehydrated-looking skin
• The delicate under-eye region (Rejuran i)
• Targeted, localised skin concerns (Rejuran S)

Treatment Course

Rejuran is typically delivered as a short course — commonly around three sessions spaced roughly two to four weeks apart — with maintenance later in the year. Because it works by supporting the skin's own repair, patients should expect gradual improvement rather than an overnight result, and outcomes depend on baseline skin condition.

Aftercare

Transient redness, swelling and small injection-point papules are commonly reported in the hours after treatment, particularly in the thin under-eye skin, and typically settle within a day or two. A cold compress and gentle handling of the area are generally sufficient. Patients should be advised that small bumps at injection points can take a short while to resolve.

Contraindications and Patient Selection

Standard injectable exclusions apply: hypersensitivity to any component, pregnancy and lactation, active infection or inflammatory skin disease at the site, and bleeding disorders. As Rejuran is derived from fish DNA, a fish-allergy history is a relevant part of screening. Autoimmune conditions warrant individual clinical judgement.

Where Rejuran Fits

Rejuran sits alongside the other polynucleotide ranges as a skin-quality tool, and complements — rather than replaces — hyaluronic-acid skinboosters and volumising treatments. For patients whose main concern is the condition of the skin, especially around the eyes, it is a well-established option.

The Takeaway

The Rejuran range covers general skin quality (Healer), the under-eye (i) and targeted work (S) through purified polynucleotides. Matching the presentation to the area and concern is the key decision. See the full polynucleotide range or the 2026 polynucleotide guide.